Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi
نویسندگان
چکیده
1Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA 2Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA 3Department of Dermatology, University Hospital Zurich, Zurich, Switzerland 4Division of Hematology-Oncology, University of Pittsburgh Medical Center, Pittsburgh, USA 5Departement of Pathology, Institute Curie, Paris, France 6Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
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ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression
TERT (telomerase reverse transcriptase) is the catalytic component of telomerase. TERT shows little expression in normal somatic cells but is commonly re-expressed in cancers, facilitating immortalization. Recently-discovered TERT promoter mutations create binding sites for ETS-family transcription factors to upregulate TERT. ETS1 is reported to be important for TERT upregulation in melanoma. H...
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